The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic – to a certain degree – organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease – and tumour modelling, correction of genetic mutations and understanding gene – and cell functions. Finally, we discuss future developments in the field.

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