A new method for growing brain organoids allows them to survive for up to a year — more than four times as long as is possible with other methods1.
Brain organoids are tiny balls of cells that mimic the structure and function of the human brain. Researchers grow them from human stem cells that they coax to become brain cells.
Organoids lack their own blood supply, so they have to be kept in a soup of nutrients. But once they reach a certain size, nutrients and oxygen can no longer reach their center, causing them to die. This decline normally begins around two to three months.
In the new study, researchers sliced up 55- to 60-day-old organoids and placed them on a porous membrane over a liquid nutrient mix of sugars, proteins, amino acids and salts. Each slice of the organoid acted as a complete organoid, the researchers say.Back to News and Media